Antibiotic pharmacokinetics in infected pleural effusions.
Thorax
; 79(9): 883-885, 2024 Aug 19.
Article
in En
| MEDLINE
| ID: mdl-38964858
ABSTRACT
Pleural infection is usually treated with empirical broad-spectrum antibiotics, but limited data exist on their penetrance into the infected pleural space. We performed a pharmacokinetic study analysing the concentration of five intravenous antibiotics across 146 separate time points in 35 patients (amoxicillin, metronidazole, piperacillin-tazobactam, clindamycin and cotrimoxazole). All antibiotics tested, apart from co-trimoxazole, reach pleural fluid levels equivalent to levels within the blood and well above the relevant minimum inhibitory concentrations. The results demonstrate that concerns about the penetration of commonly used antibiotics, apart from co-trimoxazole, into the infected pleural space are unfounded.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pleural Effusion
/
Anti-Bacterial Agents
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Thorax
Year:
2024
Document type:
Article
Country of publication:
United kingdom