Autoimmunity in patients with inborn errors of immunity: A case series.
Reumatol Clin (Engl Ed)
; 20(7): 398-400, 2024.
Article
in En
| MEDLINE
| ID: mdl-38971706
ABSTRACT
OBJECTIVE:
To assess the prevalence of systemic and organ-specific autoimmunity among individuals with human inborn errors of immunity (IEI).METHODS:
Retrospective study. We recorded demographic variables, type of immunodeficiency, and systemic and organ specific autoimmunity.RESULTS:
We included 48 patients (54.1% men) with mean age of 32.1 years. The most common IEIs included combined immunodeficiency with syndromic features (31.2%) and predominantly antibody deficiency (20.1%). We observed autoimmunity in 15 patients (31.2%) 12 organ-specific autoimmunity and 5 systemic autoimmunity, not mutually exclusive groups. Organ-specific autoimmunity preceded the onset of IEI in 5 patients, was concurrent in one patient, and developed after the diagnosis of IEI in 6 cases. From the systemic autoimmunity group, we observed polyarteritis nodosa (nâ¯=â¯2), antiphospholipid syndrome (APS) (nâ¯=â¯2), and overlap of limited systemic sclerosis/APS/Sjögren's syndrome (nâ¯=â¯1), and in all cases, this occurred after the IEI diagnosis.CONCLUSION:
Our findings confirm the coexistence of autoimmunity and IEI. This overlap may be attributed to B and T cell disorders, as well as potential alterations in the microbiota in these patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autoimmune Diseases
/
Autoimmunity
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Middle aged
Language:
En
Journal:
Reumatol Clin (Engl Ed)
Year:
2024
Document type:
Article
Affiliation country:
Mexico