The role of anti-citrullinated protein antibody in pathogenesis of RA.
Clin Exp Med
; 24(1): 153, 2024 Jul 08.
Article
in En
| MEDLINE
| ID: mdl-38972923
ABSTRACT
Rheumatoid arthritis (RA) is a common autoimmune rheumatic disease that causes chronic synovitis, bone erosion, and joint destruction. The autoantigens in RA include a wide array of posttranslational modified proteins, such as citrullinated proteins catalyzed by peptidyl arginine deiminase4a. Pathogenic anti-citrullinated protein antibodies (ACPAs) directed against a variety of citrullinated epitopes are abundant both in plasma and synovial fluid of RA patients. ACPAs play an important role in the onset and progression of RA. Intensive and extensive studies are being conducted to unveil the mechanisms of RA pathogenesis and evaluate the efficacy of some investigative drugs. In this review, we focus on the formation and pathogenic function of ACPAs.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arthritis, Rheumatoid
/
Anti-Citrullinated Protein Antibodies
Limits:
Humans
Language:
En
Journal:
Clin Exp Med
Journal subject:
MEDICINA
Year:
2024
Document type:
Article
Affiliation country:
China
Publication country:
IT
/
ITALIA
/
ITALY
/
ITÁLIA