[Advances in glucocorticoid resistance in otorhinolaryngological diseases].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
; 38(7): 661-665, 2024 Jul.
Article
in Zh
| MEDLINE
| ID: mdl-38973050
ABSTRACT
Glucocorticoidsï¼GCï¼ are widely used in the clinical treatment of autoimmune inner ear diseases, sudden sensorineural hearing loss, Meniere's disease, sinusitis and other otolaryngology diseases. However, GC resistance remains a major factor contributing to the poor efficacy of clinical treatments. The mechanism of GC resistance is still unclear. This paper reviews the related mechanisms of GC resistance from the perspectives of GC receptor factors and non-GC receptor factors. Additionally, it summarizes the latest research progress on GC resistance in otolaryngological diseases, with the aim of identifying effective clinical alternative treatment options for reversing GC resistance in the future.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Otorhinolaryngologic Diseases
/
Drug Resistance
/
Receptors, Glucocorticoid
/
Glucocorticoids
Limits:
Humans
Language:
Zh
Journal:
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
Year:
2024
Document type:
Article