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Brain clocks capture diversity and disparity in aging and dementia.
Moguilner, Sebastian; Baez, Sandra; Hernandez, Hernan; Migeot, Joaquín; Legaz, Agustina; Gonzalez-Gomez, Raul; Farina, Francesca R; Prado, Pavel; Cuadros, Jhosmary; Tagliazucchi, Enzo; Altschuler, Florencia; Maito, Marcelo Adrián; Godoy, María E; Cruzat, Josephine; Valdes-Sosa, Pedro A; Lopera, Francisco; Ochoa-Gómez, John Fredy; Hernandez, Alfredis Gonzalez; Bonilla-Santos, Jasmin; Gonzalez-Montealegre, Rodrigo A; Anghinah, Renato; d'Almeida Manfrinati, Luís E; Fittipaldi, Sol; Medel, Vicente; Olivares, Daniela; Yener, Görsev G; Escudero, Javier; Babiloni, Claudio; Whelan, Robert; Güntekin, Bahar; Yirikogullari, Harun; Santamaria-Garcia, Hernando; Lucas, Alberto Fernández; Huepe, David; Di Caterina, Gaetano; Soto-Añari, Marcio; Birba, Agustina; Sainz-Ballesteros, Agustin; Coronel-Oliveros, Carlos; Yigezu, Amanuel; Herrera, Eduar; Abasolo, Daniel; Kilborn, Kerry; Rubido, Nicolás; Clark, Ruaridh A; Herzog, Ruben; Yerlikaya, Deniz; Hu, Kun; Parra, Mario A; Reyes, Pablo.
Affiliation
  • Moguilner S; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
  • Baez S; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.
  • Hernandez H; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Migeot J; Universidad de los Andes, Bogota, Colombia.
  • Legaz A; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.
  • Gonzalez-Gomez R; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
  • Farina FR; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
  • Prado P; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
  • Cuadros J; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.
  • Tagliazucchi E; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
  • Altschuler F; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.
  • Maito MA; The University of California Santa Barbara (UCSB), California, USA.
  • Godoy ME; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
  • Cruzat J; Facultad de Odontología y Ciencias de la Rehabilitación, Universidad San Sebastián, Santiago de Chile, Chile.
  • Valdes-Sosa PA; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
  • Lopera F; Grupo de Bioingeniería, Decanato de Investigación, Universidad Nacional Experimental del Táchira, San Cristóbal 5001, Venezuela.
  • Ochoa-Gómez JF; Pontificia Universidad Javeriana (PhD Program in Neuroscience) Bogotá, San Ignacio, Colombia.
  • Hernandez AG; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
  • Bonilla-Santos J; University of Buenos Aires, Argentina.
  • Gonzalez-Montealegre RA; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.
  • Anghinah R; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
  • d'Almeida Manfrinati LE; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.
  • Fittipaldi S; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
  • Medel V; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.
  • Olivares D; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
  • Yener GG; The Clinical Hospital of Chengdu Brain Sciences, University of Electronic Sciences.
  • Escudero J; Technology of China, Chengdu, China; Cuban Neuroscience Center, La Habana, Cuba.
  • Babiloni C; Grupo de Neurociencias de Antioquia (GNA) University of Antioquia, Medellín, Colombia.
  • Whelan R; Grupo de Neurociencias de Antioquia (GNA) University of Antioquia, Medellín, Colombia.
  • Güntekin B; Department of Psychology, Master program of Clinical Neuropsychology, Universidad Surcolombiana Neiva, Neiva - Huila, Colombia.
  • Yirikogullari H; Department of Psychology, Universidad Cooperativa de Colombia.
  • Santamaria-Garcia H; Neurocognition and Psychophysiology Laboratory, Universidad Surcolombiana, Neiva - Huila, Colombia.
  • Lucas AF; Reference Center of Behavioural Disturbances and Dementia, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • Huepe D; Traumatic Brain Injury Cognitive Rehabilitation Out-Patient Center, University of Sao Paulo, Sao Paulo, Brazil.
  • Di Caterina G; Reference Center of Behavioural Disturbances and Dementia, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • Soto-Añari M; Traumatic Brain Injury Cognitive Rehabilitation Out-Patient Center, University of Sao Paulo, Sao Paulo, Brazil.
  • Birba A; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
  • Sainz-Ballesteros A; Universidad de los Andes, Bogota, Colombia.
  • Coronel-Oliveros C; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
  • Yigezu A; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
  • Herrera E; Center for Social and Cognitive Neuroscience, School of Psychology, Universidad Adolfo Ibáñez, Santiago, Chile.
  • Abasolo D; Neuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology program-Institute of Biomedical Sciences (ICBM), Neuroscience and East Neuroscience Departments, Faculty of Medicine, University of Chile, Santiago, Chile.
  • Kilborn K; Centro de Neuropsicología Clínica (CNC), Santiago, Chile.
  • Rubido N; Faculty of Medicine, Izmir University of Economics, 35330, Izmir, Turkey.
  • Clark RA; Brain Dynamics Multidisciplinary Research Center, Dokuz Eylul University, Izmir, Turkey.
  • Herzog R; Izmir Biomedicine and Genome Center, Izmir, Turkey.
  • Yerlikaya D; School of Engineering, Institute for Imaging, Data and Communications, University of Edinburgh, Scotland, UK.
  • Hu K; Department of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, Rome, Italy.
  • Parra MA; Hospital San Raffaele Cassino, Cassino, (FR), Italy.
  • Reyes P; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.
Res Sq ; 2024 Jun 25.
Article in En | MEDLINE | ID: mdl-38978575
ABSTRACT
Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding brain health and disease. However, the impact of multimodal diversity (geographical, socioeconomic, sociodemographic, sex, neurodegeneration) on the brain age gap (BAG) is unknown. Here, we analyzed datasets from 5,306 participants across 15 countries (7 Latin American countries -LAC, 8 non-LAC). Based on higher-order interactions in brain signals, we developed a BAG deep learning architecture for functional magnetic resonance imaging (fMRI=2,953) and electroencephalography (EEG=2,353). The datasets comprised healthy controls, and individuals with mild cognitive impairment, Alzheimer's disease, and behavioral variant frontotemporal dementia. LAC models evidenced older brain ages (fMRI MDE=5.60, RMSE=11.91; EEG MDE=5.34, RMSE=9.82) compared to non-LAC, associated with frontoposterior networks. Structural socioeconomic inequality and other disparity-related factors (pollution, health disparities) were influential predictors of increased brain age gaps, especially in LAC (R2=0.37, F2=0.59, RMSE=6.9). A gradient of increasing BAG from controls to mild cognitive impairment to Alzheimer's disease was found. In LAC, we observed larger BAGs in females in control and Alzheimer's disease groups compared to respective males. Results were not explained by variations in signal quality, demographics, or acquisition methods. Findings provide a quantitative framework capturing the multimodal diversity of accelerated brain aging.

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Res Sq Year: 2024 Document type: Article Affiliation country: Chile Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Res Sq Year: 2024 Document type: Article Affiliation country: Chile Country of publication: United States