Roles for PMP22 in Schwann cell cholesterol homeostasis in health and disease.
Biochem Soc Trans
; 52(4): 1747-1756, 2024 08 28.
Article
in En
| MEDLINE
| ID: mdl-38979632
ABSTRACT
Underexpression, overexpression, and point mutations in peripheral myelin protein 22 (PMP22) cause most cases of Charcot-Marie-Tooth disease (CMTD). While its exact functions remain unclear, PMP22 is clearly essential for formation and maintenance of healthy myelin in the peripheral nervous system. This review explores emerging evidence for roles of PMP22 in cholesterol homeostasis. First, we highlight dysregulation of lipid metabolism in PMP22-based forms of CMTD and recently-discovered interactions between PMP22 and cholesterol biosynthesis machinery. We then examine data that demonstrates PMP22 and cholesterol co-traffic in cells and co-localize in lipid rafts, including how disease-causing PMP22 mutations result in aberrations in cholesterol localization. Finally, we examine roles for interactions between PMP22 and ABCA1 in cholesterol efflux. Together, this emerging body of evidence suggests that PMP22 plays a role in facilitating enhanced cholesterol synthesis and trafficking necessary for production and maintenance of healthy myelin.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schwann Cells
/
Charcot-Marie-Tooth Disease
/
Cholesterol
/
Homeostasis
/
Myelin Proteins
Limits:
Animals
/
Humans
Language:
En
Journal:
Biochem Soc Trans
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
United kingdom