Drop in survivorship 13 years after AMIC procedures in aligned knees: A long-term follow-up.
Knee Surg Sports Traumatol Arthrosc
; 2024 Jul 10.
Article
in En
| MEDLINE
| ID: mdl-38984906
ABSTRACT
PURPOSE:
Autologous matrix-induced chondrogenesis (AMIC) showed promising short-term results comparable to microfracture. This study aims to assess the 19-year outcomes of AMIC, addressing the lack of long-term data.METHODS:
Retrospective cohort of 34 knees treated with AMIC underwent a 19-year follow-up. The primary outcome was AMIC survival, considering total knee arthroplasty as a failure event. Survival analysis for factors that were associated with longer survival of the AMIC was also performed. Clinical and radiological outcome scores were analysed for the AMIC group.RESULTS:
Twenty-three knees were available for follow-up analysis. Of these, 14 (61%) underwent revision surgery for total knee arthroplasty (TKA). The mean time was 13.3 ± 2.5 years (range 9-17 years). Secondary outcomes showed that increased age at surgery (hazard ratio [HR] 1.05; p = 0.021) and larger defect size (HR 1.95; p = 0.018) were risk factors for failure. Concomitant proximal tibial osteotomy (HR 0.22; p = 0.019) was associated with longer survival. The remaining nine knees (39%) were analysed as a single group. The mean clinical score at follow-up of 18.6 ± 0.9 SD years was 79.5 ± 19.7 SD for the Lysholm score, 1.8 ± 1.5 SD for the visual analog scale score, 74.2 ± 22.4 SD for the KOOS score and a median of 3 (range 3-4) for the Tegner activity scale.CONCLUSIONS:
The mean survival time of 13.3 years indicates the durability of AMIC in properly aligned knees. Nonetheless, despite a 61% conversion to TKA, the knees that persisted until the 19-year follow-up remained stable, underscoring the procedure's longevity and consistent clinical outcomes. LEVEL OF EVIDENCE Level IV.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Knee Surg Sports Traumatol Arthrosc
Journal subject:
MEDICINA ESPORTIVA
/
TRAUMATOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Switzerland