A bioactive sprite: Recent advances in the application of vinyl sulfones in drug design and organic synthesis.
Life Sci
; 352: 122904, 2024 Sep 01.
Article
in En
| MEDLINE
| ID: mdl-38986895
ABSTRACT
Vinyl sulfones, with their exceptional chemical properties, are known as the "chameleons" of organic synthesis and are widely used in the preparation of various sulfur-containing structures. However, their most alluring feature lies in their biological activity. The vinyl sulfone skeleton is ubiquitous in natural products and drug molecules and boasts a unique molecular structure and drug activity when compared to conventional drug molecules. As a result, vinyl sulfones have been extensively studied, playing a critical role in organic synthesis and pharmaceutical chemistry. In this review, we present a comprehensive analysis of the recent applications of vinyl sulfone structures in drug design, biology, and chemical synthesis. Furthermore, we explore the prospects of vinyl sulfones in diverse fields, offering insight into their potential future applications.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sulfones
/
Drug Design
Limits:
Humans
Language:
En
Journal:
Life Sci
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Netherlands