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Direct Cyanoalkylation of Imines Driven by a Photoactive Electron Donor-Acceptor Complex.
Liu, Wei; Hou, Hao; Jing, Haochuan; Huang, Shiqing; Ou, Wei; Su, Chenliang.
Affiliation
  • Liu W; International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen, Guangdong 518060, P. R. China.
  • Hou H; International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen, Guangdong 518060, P. R. China.
  • Jing H; International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen, Guangdong 518060, P. R. China.
  • Huang S; Department of Chemistry, Renmin University of China, Beijing 100872, People's Republic of China.
  • Ou W; International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen, Guangdong 518060, P. R. China.
  • Su C; International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen, Guangdong 518060, P. R. China.
Org Lett ; 26(29): 6092-6097, 2024 Jul 26.
Article in En | MEDLINE | ID: mdl-38990286
ABSTRACT
ß-Amino nitriles are important molecular scaffolds. Cyanoalkylation of imines is the most straightforward method for the construction of these scaffolds. In this study, we report the novel cyanoalkylation of imines via radical coupling enabled by a photoactive electron donor-acceptor complex. This strategy is characterized by mild conditions, broad reaction scopes, and high atom economy. The scalability and practicality of this strategy are demonstrated by a 40 g continuous flow system from which a variety of important pharmaceutical-related molecules were obtained.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2024 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2024 Document type: Article Country of publication: United States