Follow the flow: Actin and membrane act as an integrated system to globally coordinate cell shape and movement.
Curr Opin Cell Biol
; 89: 102392, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38991476
ABSTRACT
Migratory cells are polarized with protrusive fronts and contractile rears. This spatial organization necessitates long-range coordination of the signals that organize protrusions and contractions. Cells leverage reciprocal interactions of short-range biochemical signals and long-range mechanical forces for this integration. The interface between the plasma membrane and actin cortex is where this communication occurs. Here, we review how the membrane and cortex form an integrated system for long-range coordination of cell polarity. We highlight the role of membrane-to-cortex-attachment proteins as regulators of tension transmission across the cell and discuss the interplay between actin-membrane and polarity signaling complexes. Rather than presenting an exhaustive list of recent findings, we focus on important gaps in our current understanding.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Membrane
/
Cell Movement
/
Actins
/
Cell Polarity
/
Cell Shape
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Cell Biol
Year:
2024
Document type:
Article