Venous Thromboembolism Following COVID-19 Vaccination in Patients With Hereditary Protein S Deficiency.
J Hematol
; 13(3): 125-127, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38993740
ABSTRACT
Hereditary protein S (PS) deficiency is a rare condition associated with increased risk of venous thromboembolism (VTE). In 2020, the coronavirus disease 2019 (COVID-19) pandemic prompted development of vaccinations to protect against the virus. PS deficiency is not a contraindication to COVID-19 vaccinations, but there are no studies regarding potential adverse effects in this population. We report two cases, a 43-year-old mother and her 18-year-old son, who developed VTE shortly after their first COVID-19 vaccines. Testing confirmed hereditary PS deficiency with a previously undescribed mutation in both cases. The temporal association between COVID-19 vaccination and VTE in these patients with hereditary PS deficiency suggests a potential causal relationship. However, it is unclear if this applies to all patients with hereditary PS deficiency. This highlights the importance of reporting adverse events following COVID-19 vaccinations in this population to evaluate the risks and benefits of vaccination.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Hematol
Year:
2024
Document type:
Article
Affiliation country:
Canada