Therapeutic strategies targeting the epidermal growth factor receptor signaling pathway in metastatic colorectal cancer.
World J Gastrointest Oncol
; 16(6): 2362-2379, 2024 Jun 15.
Article
in En
| MEDLINE
| ID: mdl-38994135
ABSTRACT
More than 1.9 million new colorectal cancer (CRC) cases and 935000 deaths were estimated to occur worldwide in 2020, representing about one in ten cancer cases and deaths. Overall, colorectal ranks third in incidence, but second in mortality. More than half of the patients are in advanced stages at diagnosis. Treatment options are complex because of the heterogeneity of the patient population, including different molecular subtypes. Treatments have included conventional fluorouracil-based chemotherapy, targeted therapy, immunotherapy, etc. In recent years, with the development of genetic testing technology, more and more targeted drugs have been applied to the treatment of CRC, which has further prolonged the survival of metastatic CRC patients.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
World J Gastrointest Oncol
Year:
2024
Document type:
Article
Affiliation country:
China