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The Association between Diabetes Medication Use and Tumour Characteristics at Diagnosis in Patients with Urothelial Carcinoma: A Retrospective Registry-Based Study.
Faessen, Janine P M; Oerlemans, Dennis J A J; de Jong, Marc R P A; Overbeek, Jetty A; Vissers, Pauline A J; Aben, Katja K H; Janssen-Heijnen, Maryska L G; van den Bergh, Joop P W; van Osch, Frits H M.
Affiliation
  • Faessen JPM; Department of Clinical Epidemiology, VieCuri Medical Centre, Venlo, The Netherlands.
  • Oerlemans DJAJ; Department of Human Nutrition, Wageningen University & Research, Wageningen, The Netherlands.
  • de Jong MRPA; Department of Urology, Laurentius Hospital, Roermond, The Netherlands.
  • Overbeek JA; Department of Urology, VieCuri Medical Centre, Venlo, The Netherlands.
  • Vissers PAJ; PHARMO Institute for Drug Outcomes Research, Utrecht, The Netherlands.
  • Aben KKH; Department of Research and Development, Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands.
  • Janssen-Heijnen MLG; Department of Research and Development, Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands.
  • van den Bergh JPW; Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
  • van Osch FHM; Department of Clinical Epidemiology, VieCuri Medical Centre, Venlo, The Netherlands.
Bladder Cancer ; 9(1): 73-82, 2023.
Article in En | MEDLINE | ID: mdl-38994479
ABSTRACT

BACKGROUND:

Observational studies indicate a potential association between diabetes medication use and aggressiveness of bladder cancer.

OBJECTIVE:

The objective is to exploratively study the association between diabetes medication use, as proxy for diabetes, and cancer characteristics of urothelial carcinoma at diagnosis. Furthermore, differences in associations between specific types of diabetes medication are studied.

METHODS:

The association between use of diabetes medication and urothelial carcinoma (UC) characteristics at diagnosis is studied. A retrospective registry-based study among UC patients in the Netherlands was performed for which two large linked registries from PHARMO and IKNL were used. Patients diagnosed with UC between 2000 and 2016 and no previous cancer were included in this study. In this study, 1,168 UC patients who were diabetes medication users were included as well as 3,609 non-users. Conditional logistic regression analysis was performed to determine odds ratios comparing cancer characteristics between different types of diabetes medication users to non-users.

RESULTS:

Noninsulin antidiabetic drugs (NIAD) use was associated with a muscle-invasive type of UC compared to non-users (OR = 1.31, 95% CI 1.10-1.55 for T2+ versus Ta) as well as a poorly differentiated tumour (OR = 1.31, 95% CI 1.07-1.59 for poorly versus well differentiated tumours).

CONCLUSION:

Users of diabetes medication are potentially more likely to be diagnosed with a more aggressive tumour than non-users; however, lifestyle factors could not be adjusted for.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Bladder Cancer Year: 2023 Document type: Article Affiliation country: Netherlands

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Bladder Cancer Year: 2023 Document type: Article Affiliation country: Netherlands