Biological functions and potential mechanisms of miR­143­3p in cancers (Review).

ABSTRACT

In recent years, microRNAs (miRNAs or miRs) have been increasingly studied for their role in cancer and have shown potential as cancer biomarkers. miR­143­3p and miR­143­5p are the mature miRNAs derived from pre­miRNA­143. At present, there are numerous studies on the function of miR­143­3p in cancer progression, but there are no systematic reviews describing the function of miR­143­3p in cancer. It is widely considered that miR­143­3p is downregulated in most malignant tumors and that upstream regulators can act on this gene, which in turn regulates the corresponding target to act on the tumor. In addition, miRNA­143­3p can regulate target genes to affect the biological process of tumors through various signaling pathways, such as the PI3K/Akt, Wnt/ß­catenin, AKT/STAT3 and Ras­Raf­MEK­ERK pathways. The present review comprehensively described the biogenesis of miR­143­3p, the biological functions of miR­143­3p and the related roles and mechanisms in different cancer types. The potential of miR­143­3p as a biomarker for cancer was also highlighted and valuable future research directions were discussed.