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Photodynamic Effect of Amphiphilic N∧C∧N-Coordinated Platinum(II) Complexes in Human Umbilical Vein Endothelial Cells.
Hattori, Shingo; Ogishima, Mizuki; Nakajima, Tadaaki; Hosoya, Shota; Kitagawa, Yuichi; Hasegawa, Yasuchika; Nonose, Shinji; Sato, Tomomi; Shinozaki, Kazuteru.
Affiliation
  • Hattori S; Graduate School of Nanobioscience, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama 236-0027, Japan.
  • Ogishima M; Graduate School of Nanobioscience, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama 236-0027, Japan.
  • Nakajima T; Graduate School of Nanobioscience, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama 236-0027, Japan.
  • Hosoya S; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo 060-8628, Japan.
  • Kitagawa Y; Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo 060-8628, Japan.
  • Hasegawa Y; Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo 060-8628, Japan.
  • Nonose S; Graduate School of Nanobioscience, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama 236-0027, Japan.
  • Sato T; Graduate School of Nanobioscience, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama 236-0027, Japan.
  • Shinozaki K; Graduate School of Nanobioscience, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama 236-0027, Japan.
Inorg Chem ; 63(30): 13972-13979, 2024 Jul 29.
Article in En | MEDLINE | ID: mdl-38996005
ABSTRACT
Here, we report a photodynamic therapy (PDT) photosensitizer of N∧C∧N-coordinated Pt(II) complexes [Pt(L)(solv)]+ (HL = 1,3-(2-dipyridyl)benzene) and [Pt(L)]+@HSA, which is the Pt(II) complex encapsulated in human serum albumin (HSA). The quantum yield of singlet oxygen production for [Pt(L)(solv)]+ is more than 50%, while that for [Pt(L)]+@HSA is much lower. Photoimages of human umbilical vein endothelial cells (HUVECs) treated with the Pt(II) complexes suggest that [Pt(L)(solv)]+ is delocalized in the entire cell after the fast uptake by diffusion and [Pt(L)]+@HSA is taken up by endocytosis and localized on organelles and the cell membrane. [Pt(L)(solv)]+ shows high photocytotoxicity for HUVECs, while [Pt(L)]+@HSA does not show photocytotoxicity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photochemotherapy / Photosensitizing Agents / Human Umbilical Vein Endothelial Cells Limits: Humans Language: En Journal: Inorg Chem Year: 2024 Document type: Article Affiliation country: Japan Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photochemotherapy / Photosensitizing Agents / Human Umbilical Vein Endothelial Cells Limits: Humans Language: En Journal: Inorg Chem Year: 2024 Document type: Article Affiliation country: Japan Country of publication: United States