Analysis of Expression of the ANG1, CaSR and FAK Proteins in Uterine Fibroids.
Int J Mol Sci
; 25(13)2024 Jun 28.
Article
in En
| MEDLINE
| ID: mdl-39000274
ABSTRACT
Understanding the molecular factors involved in the development of uterine myomas may result in the use of pharmacological drugs instead of aggressive surgical treatment. ANG1, CaSR, and FAK were examined in myoma and peripheral tissue samples taken from women after myoma surgery and in normal uterine muscle tissue samples taken from the control group. Tests were performed using tissue microarray immunohistochemistry. No statistically significant differences in ANG1 expression between the tissue of the myoma, the periphery, and the normal uterine muscle tissue of the control group were recorded. The CaSR value was reduced in the myoma and peripheral tissue and normal in the group of women without myomas. FAK expression was also lower in the myoma and periphery compared to the healthy uterine myometrium. Calcium supplementation could have an effect on stopping the growth of myomas.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Uterine Neoplasms
/
Receptors, Calcium-Sensing
/
Focal Adhesion Kinase 1
/
Leiomyoma
Limits:
Adult
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Int J Mol Sci
Year:
2024
Document type:
Article
Affiliation country:
Poland
Country of publication:
Switzerland