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Generation of four induced pluripotent stem cell lines (KEIUi004-A, KEIUi005-A, KEIUi006-A, and KEIUi007-A) from patients with sensorineural hearing loss with mutation in EYA4 gene.
Saegusa, Chika; Mutai, Hideki; Saeki, Tsubasa; Matsuzaki, Saeko; Mizukoshi, Akifumi; Kitajiri, Shin-Ichiro; Matsunaga, Tatsuo; Hosoya, Makoto; Okano, Hideyuki; Fujioka, Masato.
Affiliation
  • Saegusa C; Department of Molecular Genetics, Kitasato University School of Medicine, Kanagawa, Japan; Molecular Genetics Unit, Kitasato University Graduate School of Medical Science, Kanagawa, Japan; Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
  • Mutai H; Department of Molecular Genetics, Kitasato University School of Medicine, Kanagawa, Japan; Molecular Genetics Unit, Kitasato University Graduate School of Medical Science, Kanagawa, Japan; Division of Hearing and Balance Research, National Institute of Sensory Organs, NHO Tokyo Medical Center, Tokyo
  • Saeki T; Department of Physiology, Keio University School of Medicine, Tokyo, Japan.
  • Matsuzaki S; Department of Molecular Genetics, Kitasato University School of Medicine, Kanagawa, Japan; Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
  • Mizukoshi A; Department of Otolaryngology Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Otolaryngology, Kyoto Katsura Hospital, Kyoto, Japan.
  • Kitajiri SI; Department of Otolaryngology Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Matsunaga T; Division of Hearing and Balance Research, National Institute of Sensory Organs, NHO Tokyo Medical Center, Tokyo, Japan; Medical Genetics Center, NHO Tokyo Medical Center, Tokyo, Japan.
  • Hosoya M; Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
  • Okano H; Department of Physiology, Keio University School of Medicine, Tokyo, Japan; Keio University Regenerative Medicine Research Center, Kanagawa, Japan; Division of CNS Regeneration and Drug Discovery, International Center for Brain Science, Fujita Health University, Aichi, Japan. Electronic address: hid
  • Fujioka M; Department of Molecular Genetics, Kitasato University School of Medicine, Kanagawa, Japan; Molecular Genetics Unit, Kitasato University Graduate School of Medical Science, Kanagawa, Japan; Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan; Clinical
Stem Cell Res ; 79: 103489, 2024 Sep.
Article in En | MEDLINE | ID: mdl-39002249
ABSTRACT
Disease-related cells differentiated from patient-derived iPSCs are useful for elucidating the pathophysiological mechanisms underlying these diseases. In this study, four iPSC lines were established from independent patients with sensorineural hearing loss and a mutation in EYA4. These iPSCs showed pluripotency, the capacity to differentiate into three germ layers, and normal karyotypes, suggesting that these lines are useful for the pathological study of sensorineural hearing loss and drug screening for ear disorders.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Induced Pluripotent Stem Cells / Hearing Loss, Sensorineural / Mutation Limits: Child / Female / Humans / Male Language: En Journal: Stem Cell Res Year: 2024 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Induced Pluripotent Stem Cells / Hearing Loss, Sensorineural / Mutation Limits: Child / Female / Humans / Male Language: En Journal: Stem Cell Res Year: 2024 Document type: Article Affiliation country: Japan