The roles of dietary polyphenols at crosstalk between type 2 diabetes and Alzheimer's disease in ameliorating oxidative stress and mitochondrial dysfunction via PI3K/Akt signaling pathways.
Ageing Res Rev
; 99: 102416, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-39002644
ABSTRACT
Alzheimer's disease (AD) is a fatal neurodegenerative disease in which senile plaques and neurofibrillary tangles are crucially involved in its physiological and pathophysiological processes. Growing animal and clinical studies have suggested that AD is also comorbid with some metabolic diseases, including type 2 diabetes mellitus (T2DM), and therefore, it is often considered brain diabetes. AD and T2DM share multiple molecular and biochemical mechanisms, including impaired insulin signaling, oxidative stress, gut microbiota dysbiosis, and mitochondrial dysfunction. In this review article, we mainly introduce oxidative stress and mitochondrial dysfunction and explain their role and the underlying molecular mechanism in T2DM and AD pathogenesis; then, according to the current literature, we comprehensively evaluate the possibility of regulating oxidative homeostasis and mitochondrial function as therapeutics against AD. Furthermore, considering dietary polyphenols' antioxidative and antidiabetic properties, the strategies for applying them as potential therapeutical interventions in patients with AD symptoms are assessed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Oxidative Stress
/
Diabetes Mellitus, Type 2
/
Alzheimer Disease
/
Polyphenols
/
Mitochondria
Limits:
Animals
/
Humans
Language:
En
Journal:
Ageing Res Rev
/
Ageing res. rev
/
Ageing research reviews
Journal subject:
GERIATRIA
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United kingdom