TracrRNA reprogramming enables direct PAM-independent detection of RNA with diverse DNA-targeting Cas12 nucleases.

Jiao, Chunlei; Peeck, Natalia L; Yu, Jiaqi; Ghaem Maghami, Mohammad; Kono, Sarah; Collias, Daphne; Martinez Diaz, Sandra L; Larose, Rachael; Beisel, Chase L

Jiao, Chunlei; Peeck, Natalia L; Yu, Jiaqi; Ghaem Maghami, Mohammad; Kono, Sarah; Collias, Daphne; Martinez Diaz, Sandra L; Larose, Rachael; Beisel, Chase L.

Affiliation

Jiao C; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), Würzburg, Germany.
Peeck NL; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), Würzburg, Germany.
Yu J; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), Würzburg, Germany.
Ghaem Maghami M; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), Würzburg, Germany.
Kono S; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), Würzburg, Germany.
Collias D; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), Würzburg, Germany.
Martinez Diaz SL; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), Würzburg, Germany.
Larose R; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), Würzburg, Germany.
Beisel CL; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), Würzburg, Germany. chase.beisel@helmholtz-hiri.de.

Nat Commun ; 15(1): 5909, 2024 Jul 13.

Article in En | MEDLINE | ID: mdl-39003282

Subject(s)

CRISPR-Cas Systems; RNA, Guide, CRISPR-Cas Systems; RNA, Guide, CRISPR-Cas Systems/metabolism; RNA, Guide, CRISPR-Cas Systems/genetics; CRISPR-Associated Proteins/metabolism; CRISPR-Associated Proteins/genetics; RNA, Ribosomal, 16S/genetics; RNA, Ribosomal, 16S/metabolism; DNA/metabolism; DNA/genetics; RNA/metabolism; RNA/genetics; DNA Cleavage; Clustered Regularly Interspaced Short Palindromic Repeats/genetics; Bacterial Proteins/metabolism; Bacterial Proteins/genetics; Gene Editing/methods; Endodeoxyribonucleases/metabolism; Endodeoxyribonucleases/genetics; Francisella/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CRISPR-Cas Systems / RNA, Guide, CRISPR-Cas Systems Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2024 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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