Clopidogrel resistance and its effect on clinical outcomes in acute coronary syndrome.
Indian Heart J
; 76(4): 268-270, 2024.
Article
in En
| MEDLINE
| ID: mdl-39009080
ABSTRACT
AIM:
The genetic polymorphism of CYP2C19 influences clopidogrel metabolism and resistance. Aim was to assess the association between CYP2C19 loss of function variation, clopidogrel resistance based on platelet reactivity units and clinical outcomes.METHODS:
A total of 668 patients of Acute Coronary Sundrome (ACS) who underwent Percutaneous Coronary Intervention (PCI) were subjected to genetic screening and 143 patients undrewent platelet function test to study the association between drug metabolization and its effects based on platelet reactivity unit values.RESULTS:
Clopidogrel resistance with CYP2C 19 loss of function variation was noted in 54.64% of patients. Clinical outcomes, such as target vessel revascularization, target lesion revascularization, in-stent restenosis, and stent thrombosis, were also studied.CONCLUSION:
CYP2C19 loss of function variation is strongly associated with clopidogrel resistance and adverse clinical outcomes.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Resistance
/
Platelet Aggregation Inhibitors
/
Acute Coronary Syndrome
/
Percutaneous Coronary Intervention
/
Cytochrome P-450 CYP2C19
/
Clopidogrel
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Indian Heart J
Year:
2024
Document type:
Article
Country of publication:
India