[Immunomodulation in the tumor microenvironment: Therapeutic potential of combined inhibition of tumor hypoxia and PD-1/ PD-L1]. / Immunmoduláció a tumor mikrokörnyezetében: a tumorhipoxia és a PD-1/PD-L1 együttes gátlásának terápiás lehetoségei.
Magy Onkol
; 68(2): 126-135, 2024 Jul 16.
Article
in Hu
| MEDLINE
| ID: mdl-39013086
ABSTRACT
Tumor hypoxia plays an important role in controlling tumor progression through signaling pathways related to the transcription factor HIF-1. In addition to enhancing migration, promoting angiogenesis and regulating metabolism, the hypoxic environment also affects immune function. In this hypoxic microenvironment an immunosuppressive milieu is established, where HIF-1 upregulates the expression of PD-L1, a key regulator of the immune response. We have found that elevated expression of PD-L1 correlates with increased HIF-1 levels in cancer cell lines and clinical samples. Thus, the co-inhibition of HIF-1 and PD-1/PD-L1 offers promising therapeutic possibilities. In this review we have examined the limitations of HIF-1 and PD-1/PD-L1 inhibition as monotherapy, explored their combined benefits and evaluated the feasibility of targeting PD-L1 with HIF-1 inhibitors.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tumor Microenvironment
/
B7-H1 Antigen
/
Programmed Cell Death 1 Receptor
/
Tumor Hypoxia
/
Neoplasms
Limits:
Humans
Language:
Hu
Journal:
Magy Onkol
Journal subject:
NEOPLASIAS
Year:
2024
Document type:
Article
Affiliation country:
Hungary