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Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm.
Jiang, Yuchao; Luo, Cheng; Wang, Jijun; Palaniyappan, Lena; Chang, Xiao; Xiang, Shitong; Zhang, Jie; Duan, Mingjun; Huang, Huan; Gaser, Christian; Nemoto, Kiyotaka; Miura, Kenichiro; Hashimoto, Ryota; Westlye, Lars T; Richard, Genevieve; Fernandez-Cabello, Sara; Parker, Nadine; Andreassen, Ole A; Kircher, Tilo; Nenadic, Igor; Stein, Frederike; Thomas-Odenthal, Florian; Teutenberg, Lea; Usemann, Paula; Dannlowski, Udo; Hahn, Tim; Grotegerd, Dominik; Meinert, Susanne; Lencer, Rebekka; Tang, Yingying; Zhang, Tianhong; Li, Chunbo; Yue, Weihua; Zhang, Yuyanan; Yu, Xin; Zhou, Enpeng; Lin, Ching-Po; Tsai, Shih-Jen; Rodrigue, Amanda L; Glahn, David; Pearlson, Godfrey; Blangero, John; Karuk, Andriana; Pomarol-Clotet, Edith; Salvador, Raymond; Fuentes-Claramonte, Paola; Garcia-León, María Ángeles; Spalletta, Gianfranco; Piras, Fabrizio; Vecchio, Daniela.
Affiliation
  • Jiang Y; Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.
  • Luo C; Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China.
  • Wang J; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, China.
  • Palaniyappan L; High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, China.
  • Chang X; Research Unit of NeuroInformation (2019RU035), Chinese Academy of Medical Sciences, Chengdu, China.
  • Xiang S; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Zhang J; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Canada.
  • Duan M; Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.
  • Huang H; Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China.
  • Gaser C; Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.
  • Nemoto K; Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China.
  • Miura K; Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.
  • Hashimoto R; Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China.
  • Westlye LT; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, China.
  • Richard G; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, China.
  • Fernandez-Cabello S; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
  • Parker N; Department of Neurology, Jena University Hospital, Jena, Germany.
  • Andreassen OA; German Center for Mental Health (DZPG), Site Jena-Magdeburg-Halle, Magdeburg, Germany.
  • Kircher T; Department of Psychiatry, Division of Clinical Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Nenadic I; Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan.
  • Stein F; Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan.
  • Thomas-Odenthal F; Department of Psychology, University of Oslo, Oslo, Norway.
  • Teutenberg L; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Usemann P; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway.
  • Dannlowski U; Department of Psychology, University of Oslo, Oslo, Norway.
  • Hahn T; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Grotegerd D; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway.
  • Meinert S; Department of Psychology, University of Oslo, Oslo, Norway.
  • Lencer R; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Tang Y; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway.
  • Zhang T; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Li C; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Yue W; Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, Marburg, Germany.
  • Zhang Y; Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, Marburg, Germany.
  • Yu X; Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, Marburg, Germany.
  • Zhou E; Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, Marburg, Germany.
  • Lin CP; Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, Marburg, Germany.
  • Tsai SJ; Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, Marburg, Germany.
  • Rodrigue AL; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
  • Glahn D; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
  • Pearlson G; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
  • Blangero J; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
  • Karuk A; Institute for Translational Neuroscience, University of Münster, Münster, Germany.
  • Pomarol-Clotet E; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
  • Salvador R; Department of Psychiatry and Psychotherapie and Center for Brain, Behavior and Metabolism, Lübeck University, Lübeck, Germany.
  • Fuentes-Claramonte P; Institute for Transnational Psychiatry and Otto Creutzfeldt Center for Behavioral and Cognitive Neuroscience, University of Münster, Münster, Germany.
  • Garcia-León MÁ; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Spalletta G; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Piras F; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Vecchio D; Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, PR China.
Nat Commun ; 15(1): 5996, 2024 Jul 17.
Article in En | MEDLINE | ID: mdl-39013848
ABSTRACT
Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy subjects pooled across 41 international cohorts from the ENIGMA, non-ENIGMA cohorts and public datasets. Using the Subtype and Stage Inference (SuStaIn) algorithm, we identify two distinct neurostructural subgroups by mapping the spatial and temporal 'trajectory' of gray matter change in schizophrenia. Subgroup 1 was characterized by an early cortical-predominant loss with enlarged striatum, whereas subgroup 2 displayed an early subcortical-predominant loss in the hippocampus, striatum and other subcortical regions. We confirmed the reproducibility of the two neurostructural subtypes across various sample sites, including Europe, North America and East Asia. This imaging-based taxonomy holds the potential to identify individuals with shared neurobiological attributes, thereby suggesting the viability of redefining existing disorder constructs based on biological factors.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizophrenia / Algorithms / Magnetic Resonance Imaging / Gray Matter Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: America do norte / Europa Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2024 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizophrenia / Algorithms / Magnetic Resonance Imaging / Gray Matter Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: America do norte / Europa Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2024 Document type: Article Affiliation country: China