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Point mutation P174L of the penA gene endowing ceftazidime resistance to Burkholderia pseudomallei in China.
Tian, Shen; Wu, Xingyong; Liu, Lin; Li, Anyang; Li, Xuemiao; Pei, Hua; Wang, Yanshuang; Dance, David A B; Chen, Hai; Xia, Qianfeng.
Affiliation
  • Tian S; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine and The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China.
  • Wu X; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine and The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China.
  • Liu L; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine and The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China.
  • Li A; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine and The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China.
  • Li X; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine and The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China.
  • Pei H; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine and The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China.
  • Wang Y; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine and The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China.
  • Dance DAB; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Lao Democratic People's Republic; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, UK; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropica
  • Chen H; Department of Clinical Laboratory, People's Hospital of Sanya, Sanya, Hainan, China.
  • Xia Q; NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine and The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China. Electronic address: xiaqianfeng@haimnc.edu.cn.
Drug Resist Updat ; 76: 101121, 2024 Sep.
Article in En | MEDLINE | ID: mdl-39018660
ABSTRACT
In a clinical isolate of Burkholderia pseudomallei from Hainan, the association between the emergence of ceftazidime resistance and a novel PenA P174L allele was identified for the first time, providing an understanding of one mechanism by which ceftazidime resistance arises in B. pseudomallei.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microbial Sensitivity Tests / Ceftazidime / Burkholderia pseudomallei / Point Mutation / Drug Resistance, Bacterial / Melioidosis / Anti-Bacterial Agents Limits: Humans Country/Region as subject: Asia Language: En Journal: Drug Resist Updat Journal subject: ANTINEOPLASICOS Year: 2024 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microbial Sensitivity Tests / Ceftazidime / Burkholderia pseudomallei / Point Mutation / Drug Resistance, Bacterial / Melioidosis / Anti-Bacterial Agents Limits: Humans Country/Region as subject: Asia Language: En Journal: Drug Resist Updat Journal subject: ANTINEOPLASICOS Year: 2024 Document type: Article