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Using absorbance detection for hs-SV-AUC characterization of adeno-associated virus.
Larson, Nicholas R; Bou-Assaf, George M; Laue, Thomas M; Berkowitz, Steven A.
Affiliation
  • Larson NR; Analytical Development, Biogen, 225 Binney St, Cambridge, MA, 02142, USA.
  • Bou-Assaf GM; Analytical Development, Biogen, 225 Binney St, Cambridge, MA, 02142, USA.
  • Laue TM; Carpenter Professor Emeritus, University of New Hampshire, 10 Kelsey Road, Lee, NH, 03861, USA.
  • Berkowitz SA; 34 Bowker Drive, Sudbury, MA, 01776, USA. Electronic address: steveberko@comcast.net.
Anal Biochem ; 694: 115617, 2024 Nov.
Article in En | MEDLINE | ID: mdl-39019206
ABSTRACT
Data are presented demonstrating that absorbance detection can be used during high-speed sedimentation velocity analytical ultracentrifugation (hs-SV-AUC) experiments to characterize the size distribution of adeno-associated virus (AAV) drug products accurately. Advantages and limitations of being able to use this detector in this specific type of SV-AUC experiment are discussed.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ultracentrifugation / Dependovirus Limits: Humans Language: En Journal: Anal Biochem Year: 2024 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ultracentrifugation / Dependovirus Limits: Humans Language: En Journal: Anal Biochem Year: 2024 Document type: Article Affiliation country: United States Country of publication: United States