Antibacterial and oral tissue effectiveness of a mouthwash with a novel active system of amine + zinc lactate + fluoride.
Clin Exp Dent Res
; 10(4): e874, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-39023214
ABSTRACT
OBJECTIVES:
Reflecting the need for an effective support for the daily oral hygiene routine of patients experiencing (symptoms of) gum inflammation, a new mouthwash has been developed containing an amine + zinc lactate + fluoride system. The in vitro efficacy of this product was assessed using traditional laboratory methods, as well as novel experimentation. MATERIALS ANDMETHODS:
This mouthwash has been evaluated in a series of laboratory tests including two short interval kill tests (SIKTs), a 12-h (longer term) biofilm regrowth assay, a plaque glycolysis assay, and an aerobic, repeated exposure biofilm model, as well as tests for soft tissue uptake and LPS neutralization.RESULTS:
Several laboratory studies demonstrate that a mouthwash containing an amine + zinc lactate + fluoride system provides short-term and long-term antibacterial activity. While the immediate efficacy of this formula has been shown to be driven by the presence of the amine, zinc lactate provides a long-term antibacterial effect, as well as is able to inhibit bacterial metabolism.CONCLUSIONS:
This research provides the basis for understanding the mode of action of this new mouthwash formulation and explains the previously observed clinical efficacy of this formula against plaque and gingivitis.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biofilms
/
Dental Plaque
/
Fluorides
/
Anti-Bacterial Agents
/
Mouthwashes
Limits:
Humans
Language:
En
Journal:
Clin Exp Dent Res
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
United States