Solution studies, synthesis and antibacterial activity of Ga(III) complexes with bis-kojate derivatives.
J Inorg Biochem
; 259: 112663, 2024 Oct.
Article
in En
| MEDLINE
| ID: mdl-39024775
ABSTRACT
Given the recognized major problem of microbial drug resistance for human health, new metal-based drugs have been currently explored for their antimicrobial properties, including gallium-based compounds as potential metallophores that could perturb Fe's interactions with proteins. Herein we have designed and synthesized two bis-kojate ligands (named L4 and L6) and studied their Ga(III) complexes for their physico-chemical and biological properties. In particular a detailed study of their complexation properties in aqueous solution, showed equilibrium models with formation of quite stable dinuclear 23 metalligand complexes, though with different stability. Solid state complexes were also prepared and characterized and complementary DFT studies indicated that [Ga2(L4)3] complex, with higher stability, seems to adopt a three-ligand bridging conformation, while that for L6 adopt a one ligand bridging conformation. Preliminary investigation of the antibacterial activity of these gallium complexes showed antipseudomonal activity, which appeared higher for the complex with L4, a feature of potential interest for the scientific community.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Microbial Sensitivity Tests
/
Coordination Complexes
/
Gallium
/
Anti-Bacterial Agents
Language:
En
Journal:
J Inorg Biochem
Year:
2024
Document type:
Article
Affiliation country:
Ireland
Country of publication:
United States