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Plasma neurofilament light protein is differentially associated with age in individuals with treatment-resistant schizophrenia and bipolar affective disorder compared to controls.
Wannan, Cassandra M J; Eratne, Dhamidhu; Santillo, Alexander F; Malpas, Charles; Cilia, Brandon; Dean, Olivia M; Walker, Adam; Berk, Michael; Bousman, Chad; Everall, Ian; Velakoulis, Dennis; Pantelis, Christos.
Affiliation
  • Wannan CMJ; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia; Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia; Orygen, Parkville, Victoria, Australia. Electronic address: wannanc@unimelb.edu.au.
  • Eratne D; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia; Neuropsychiatry Centre, The Royal Melbourne Hospital, Melbourne, VIC, Australia.
  • Santillo AF; Department of Clinical Sciences, Clinical Memory Research Unit, Faculty of Medicine, Lund University, Lund/Malmö, Sweden.
  • Malpas C; Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Australia; Melbourne School of Psychological Sciences, University of Melbourne, Australia.
  • Cilia B; Neuropsychiatry Centre, The Royal Melbourne Hospital, Melbourne, VIC, Australia.
  • Dean OM; Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia; Florey Institute of Neuroscience and Mental Health, Parkville, Australia.
  • Walker A; Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia.
  • Berk M; Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia.
  • Bousman C; Department of Medical Genetics, University of Calgary, Calgary, Canada; Department of Psychiatry, University of Melbourne, Melbourne, Australia.
  • Everall I; Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Velakoulis D; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia; Neuropsychiatry Centre, The Royal Melbourne Hospital, Melbourne, VIC, Australia.
  • Pantelis C; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia; Department of Psychiatry, University of Melbourne, Melbourne, Australia; Western Centre for Health Research & Education, University of Melbourne & Western Health, Sunshine Hosp
Psychiatry Res ; 339: 116073, 2024 Jul 04.
Article in En | MEDLINE | ID: mdl-39024892
ABSTRACT
Accelerated brain ageing has been observed in multiple psychiatric disorders. This study examined whether relationships between age and plasma neurofilament light (NfL) protein differed in individuals with psychiatric disorders (major depressive disorder (n = 42), bipolar affective disorder (n = 121), treatment-resistant schizophrenia (TRS, n = 82)) compared to two healthy control (HC) groups (n = 1,926 and n = 59). Compared to two independent HC samples, individuals with TRS demonstrated a stronger positive relationship between age and NfL levels. Individuals with BPAD had a stronger negative relationship between age and NfL levels compared to the large normative HC cohort, but not locally-acquired HCs. These findings show that plasma NfL levels are differentially associated with age in individuals with TRS and BPAD compared to healthy individuals.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Psychiatry Res Year: 2024 Document type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Psychiatry Res Year: 2024 Document type: Article