Changes at small intestine induced by food-fish contaminated with ciguatoxins.
Ecotoxicol Environ Saf
; 282: 116741, 2024 Sep 01.
Article
in En
| MEDLINE
| ID: mdl-39024956
ABSTRACT
Ciguateric syndrome is a food poisoning associated with the consumption of some species of fish that have accumulated ciguatoxins (CTXs) in their tissues. The effects of the syndrome occur with nervous imbalances which have been described for quite some time, and mentioned in sailing literature for centuries. In the last decade, research has been focused on the implementation of analytical methods for toxin identification and the study of action modes of CTXs to design effective treatments. However, an important aspect is to determine the damage that CTXs caused in the organs of affected individuals. In this work, the damages observed in tissues of mice, mainly in the small intestine, were analyzed. The animals were fed with CTX-contaminated fish muscle at concentrations 10-times below the median lethal dose (LD50) for 10 weeks. The analysis of tissues derived from the oral treatment resulted in an increased occurrence of Paneth cells, presence of lymphoid tissue infiltrating the mucosa and fibrous lesions in the mucosal layer of the small intestine. A decreasing weight in animals fed with toxic muscle was observed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ciguatoxins
/
Fishes
/
Intestine, Small
Limits:
Animals
Language:
En
Journal:
Ecotoxicol Environ Saf
Year:
2024
Document type:
Article
Country of publication:
Netherlands