Agonist-dependent action of the juvenile hormone receptor.
Curr Opin Insect Sci
; 65: 101234, 2024 Oct.
Article
in En
| MEDLINE
| ID: mdl-39025365
ABSTRACT
Juvenile hormone (JH) signaling is realized at the gene regulatory level by receptors of the bHLH-PAS transcription factor family. The sesquiterpenoid hormones and their synthetic mimics are agonist ligands of a unique JH receptor (JHR) protein, methoprene-tolerant (MET). Upon binding an agonist to its PAS-B cavity, MET dissociates from a cytoplasmic chaperone complex including HSP83 and concomitantly switches to a bHLH-PAS partner taiman, forming a nuclear, transcriptionally active JHR heterodimer. This course of events resembles the vertebrate aryl hydrocarbon receptor (AHR), activated by a plethora of endogenous and synthetic compounds. Like in AHR, the pliable PAS-B cavity of MET adjusts to diverse ligands and binds them through similar mechanisms. Despite recent progress, we only begin to discern agonist-induced conformational shifts within the PAS-B domain, with the ultimate goal of understanding how these localized changes stimulate the assembly of the active JHR complex and, thus, fully grasp the mechanism of JHR signaling.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Juvenile Hormones
Limits:
Animals
Language:
En
Journal:
Curr Opin Insect Sci
/
Curr. Opin. Insect. Sci
/
Current opinion in insect science (Online)
Year:
2024
Document type:
Article
Country of publication:
Netherlands