Relationship between polycystic ovary syndrome and high periostin level.
Rev Assoc Med Bras (1992)
; 70(6): e20240138, 2024.
Article
in En
| MEDLINE
| ID: mdl-39045965
ABSTRACT
OBJECTIVE:
There is growing evidence suggesting a relationship between periostin levels, inflammation, and ovarian dysfunction. In this prospective case-control study, we aimed to investigate serum periostin levels and their relationship with metabolic parameters in patients with polycystic ovary syndrome.METHODS:
We conducted a prospective case-control study involving 45 polycystic ovary syndrome patients and 45 control subjects, matched in a 11 ratio. Serum samples collected from both study and control groups were analyzed using enzyme-linked immunosorbent assay.RESULTS:
The demographic characteristics were similar between the polycystic ovary syndrome and control groups (p>0.05). Periostin levels were significantly higher in patients with polycystic ovary syndrome compared with the control group (4.67±2.46 vs. 2.60±1.41 ng/mL, respectively; p=0.000).CONCLUSION:
Our study revealed a significant elevation in periostin levels among polycystic ovary syndrome patients compared with controls. These findings suggest that periostin could serve as a potential marker for assessing disease severity in polycystic ovary syndrome patients.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polycystic Ovary Syndrome
/
Enzyme-Linked Immunosorbent Assay
/
Biomarkers
/
Cell Adhesion Molecules
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Rev Assoc Med Bras (1992)
Year:
2024
Document type:
Article
Affiliation country:
Turkey