Nomogram models predicting prognosis for patients with t(8;21) acute myeloid leukemia: a SEER-based study.
Hematology
; 29(1): 2381169, 2024 Dec.
Article
in En
| MEDLINE
| ID: mdl-39046131
ABSTRACT
BACKGROUND:
Acute myeloid leukemia (AML) with t(8;21) manifests as a diverse hematological malignancy. Although it was categorized into a favorable subtype, 30-40% of patients experience relapse. The objective of this research was to devise a nomogram for the accurate anticipation of both overall survival (OS) and cancer-specific survival (CSS) in t(8;21) AML.METHODS:
From the Surveillance, Epidemiology, and End Results (SEER) database, individuals diagnosed with t(8;21) AML from 2000 to 2018 were selected. Prognostic factors for t(8;21) AML were identified using Cox regression analysis and Akaike Information Criterion (AIC), forming the basis for constructing prognostic nomograms.RESULTS:
Key variables, including first primary tumor, age group, race, and chemotherapy, were identified and integrated into the nomogram. The C-index values for the nomograms predicting OS and CSS were 0.753 (validation 0.765) and 0.764 (validation 0.757), respectively. Ultimately, based on nomogram scores, patients were stratified into high-risk and low-risk groups, revealing significant disparities in both OS and CSS between these groups (P < 0.001).CONCLUSION:
This study innovatively crafted nomograms, incorporating clinical and therapeutic variables, to forecast the 1-, 3-, and 5-year survival rates for individuals with t(8;21) AML.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromosomes, Human, Pair 8
/
Chromosomes, Human, Pair 21
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Leukemia, Myeloid, Acute
/
SEER Program
/
Nomograms
Limits:
Adolescent
/
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Hematology
Journal subject:
HEMATOLOGIA
Year:
2024
Document type:
Article