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Deep learning-based material decomposition of iodine and calcium in mobile photon counting detector CT.
Han, Kwanhee; Ryu, Chang Ho; Lee, Chang-Lae; Han, Tae Hee.
Affiliation
  • Han K; Health & Medical Equipment Business Unit, Samsung Electronics, Suwon-si, Gyeonggi-do, Korea.
  • Ryu CH; Department of Digital Media and Communications Engineering, Sungkyunkwan University, Suwon-si, Gyeonggi-do, Korea.
  • Lee CL; Department of Artificial Intelligence, Sungkyunkwan University, Suwon-si, Gyeonggi-do, Korea.
  • Han TH; Health & Medical Equipment Business Unit, Samsung Electronics, Suwon-si, Gyeonggi-do, Korea.
PLoS One ; 19(7): e0306627, 2024.
Article in En | MEDLINE | ID: mdl-39058758
ABSTRACT
Photon-counting detector (PCD)-based computed tomography (CT) offers several advantages over conventional energy-integrating detector-based CT. Among them, the ability to discriminate energy exhibits significant potential for clinical applications because it provides material-specific information. That is, material decomposition (MD) can be achieved through energy discrimination. In this study, deep learning-based material decomposition was performed using live animal data. We propose MD-Unet, which is a deep learning strategy for material decomposition based on an Unet architecture trained with data from three energy bins. To mitigate the data insufficiency, we developed a pretrained model incorporating various simulation data forms and augmentation strategies. Incorporating these approaches into model training results in enhanced precision in material decomposition, thereby enabling the identification of distinct materials at individual pixel locations. The trained network was applied to the acquired animal data to evaluate material decomposition results. Compared with conventional methods, the newly generated MD-Unet demonstrated more accurate material decomposition imaging. Moreover, the network demonstrated an improved material decomposition ability and significantly reduced noise. In addition, they can potentially offer an enhancement level similar to that of a typical contrast agent. This implies that it can acquire images of the same quality with fewer contrast agents administered to patients, thereby demonstrating its significant clinical value.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tomography, X-Ray Computed / Calcium / Photons / Deep Learning / Iodine Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2024 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tomography, X-Ray Computed / Calcium / Photons / Deep Learning / Iodine Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2024 Document type: Article Country of publication: United States