Gambogenic acid induces apoptosis via upregulation of Noxa in oral squamous cell carcinoma.
Chin J Nat Med
; 22(7): 632-642, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-39059832
ABSTRACT
Gambogenic acid (GNA), a bioactive compound derived from the resin of Garcinia hanburyi, has demonstrated significant antitumor properties. However, its mechanisms of action in oral squamous cell carcinoma (OSCC) remain largely unclear. This study aimed to elucidate the apoptotic effects of GNA on OSCC cell lines CAL-27 and SCC-15. Our results indicated that GNA induced apoptosis by upregulating the pro-apoptotic protein Noxa. Mechanistic investigations revealed that GNA treatment led to the generation of reactive oxygen species (ROS), which activated endoplasmic reticulum (ER) stress, culminating in cell apoptosis. Inhibition of ROS production and ER stress pathways significantly mitigated GNA-induced Noxa upregulation and subsequent apoptosis. Furthermore, in vivo studies using a murine xenograft model demonstrated that GNA administration effectively inhibited the growth of CAL-27 tumors. Collectively, these findings underscore GNA's potential as a therapeutic agent for the treatment of OSCC.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Xanthenes
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Mouth Neoplasms
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Carcinoma, Squamous Cell
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Up-Regulation
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Reactive Oxygen Species
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Apoptosis
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Proto-Oncogene Proteins c-bcl-2
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Garcinia
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Endoplasmic Reticulum Stress
Limits:
Animals
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Humans
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Male
Language:
En
Journal:
Chin J Nat Med
/
Chin. J. Nat. Med
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Chinese journal of natural medicines
Year:
2024
Document type:
Article
Country of publication:
China