Early Life Adversity, Microbiome, and Inflammatory Responses.
Biomolecules
; 14(7)2024 Jul 06.
Article
in En
| MEDLINE
| ID: mdl-39062516
ABSTRACT
Early life adversity has a profound impact on physical and mental health. Because the central nervous and immune systems are not fully mature at birth and continue to mature during the postnatal period, a bidirectional interaction between the central nervous system and the immune system has been hypothesized, with traumatic stressors during childhood being pivotal in priming individuals for later adult psychopathology. Similarly, the microbiome, which regulates both neurodevelopment and immune function, also matures during childhood, rendering this interaction between the brain and the immune system even more complex. In this review, we provide evidence for the role of the immune response and the microbiome in the deleterious effects of early life adversity, both in humans and rodent models.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Microbiota
/
Adverse Childhood Experiences
/
Inflammation
Limits:
Animals
/
Humans
Language:
En
Journal:
Biomolecules
Year:
2024
Document type:
Article
Affiliation country:
United States