Association of Dietary Selenium Intake with Type 2 Diabetes in Middle-Aged and Older Adults in China.
Nutrients
; 16(14)2024 Jul 21.
Article
in En
| MEDLINE
| ID: mdl-39064810
ABSTRACT
The relationship between distinct dietary selenium intake and type 2 diabetes (T2D) is still a topic of uncertainty. This study examined the relationship between dietary selenium intake and T2D risk among middle-aged and older Chinese adults. Dietary selenium intake was assessed through three 24 h recalls, using data from the China Health and Nutrition Survey. To investigate the relationship and the potential dose-response pattern between selenium intake and the likelihood of developing T2D, we employed both the restricted cubic spline analysis and the Cox proportional hazards model as our analytical tools. A cohort of 5970 participants aged ≥ 50 years was followed for an average of 5.44 years. The results revealed a V-shaped correlation between selenium intake and T2D risk, with the lowest risk observed at approximately 45 µg/day. Below this level, the risk decreased with an increasing selenium intake, while the risk increased between 45 and 100 µg/day. No significant association was found beyond 100 µg/day. These findings suggest that both low and high selenium consumption may increase T2D risk, highlighting the importance of maintaining a balanced selenium intake for T2D prevention.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Selenium
/
Diabetes Mellitus, Type 2
/
Diet
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Nutrients
Year:
2024
Document type:
Article
Affiliation country:
China