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Naphthalimide-Based, Single-Chromophore, Emission Ratiometric Fluorescent Sensor for Tracking Intracellular pH.
Kumar Das, Sujit; Kahali, Smitaroopa; Kar, Sabnam; Madhavan, Nandita; Datta, Ankona.
Affiliation
  • Kumar Das S; Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai, 400005, India.
  • Kahali S; Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai, 400005, India.
  • Kar S; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, 400076, India.
  • Madhavan N; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, 400076, India.
  • Datta A; Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai, 400005, India.
Chembiochem ; : e202400538, 2024 Jul 29.
Article in En | MEDLINE | ID: mdl-39073268
ABSTRACT
We report a novel, reversible, cell-permeable, pH-sensor, TRapH. TRapH afforded a pH-sensitive ratiometric emission response in the pH range ~3-6, enabling imaging and quantification of pH in living cells. The biological-applicability of TRapH was illustrated via live-tracking of intracellular pH dynamics in living mammalian cells induced by a synthetic H+-transporter.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2024 Document type: Article Affiliation country: India Country of publication: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2024 Document type: Article Affiliation country: India Country of publication: Germany