Chemo-enzymatic total synthesis: current approaches toward the integration of chemical and enzymatic transformations.
Beilstein J Org Chem
; 20: 1693-1712, 2024.
Article
in En
| MEDLINE
| ID: mdl-39076288
ABSTRACT
A steadily increasing number of reports have been published on chemo-enzymatic synthesis methods that integrate biosynthetic enzymatic transformations with chemical conversions. This review focuses on the total synthesis of natural products and classifies the enzymatic reactions into three categories. The total synthesis of five natural products cotylenol, trichodimerol, chalcomoracin, tylactone, and saframycin A, as well as their analogs, is outlined with an emphasis on comparing these chemo-enzymatic syntheses with the corresponding natural biosynthetic pathways.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Beilstein J Org Chem
Year:
2024
Document type:
Article
Affiliation country:
Japan