Flow Cytometry-based Immune Phenotyping of T and B Lymphocytes in the Evaluation of Immunodeficiency and Immune Dysregulation.
Clin Lab Med
; 44(3): 479-493, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-39089753
ABSTRACT
There are approximately 500 congenital disorders that impair immune cell development and/or function. Patients with these disorders may present with a wide range of symptoms, including increased susceptibility to infection, autoimmunity, autoinflammation, lymphoproliferation, and/or atopy. Flow cytometry-based immune phenotyping of T and B lymphocytes plays an essential role in the evaluation of patients with these presentations. In this review, we describe the clinical utility of flow cytometry as part of a comprehensive evaluation of immune function and how this testing may be used as a diagnostic tool to identify underlying aberrant immune pathways, monitor disease activity, and assess infection risk.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
B-Lymphocytes
/
T-Lymphocytes
/
Immunophenotyping
/
Flow Cytometry
Limits:
Humans
Language:
En
Journal:
Clin Lab Med
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
United States