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Novel thiomaleimide-based fluorescent probe with aggregation-induced emission for detecting H2S.
Kong, Yaqiong; Qin, Guoxu; Liu, Zhijun; Cheng, Lehua; Wang, Chunyu; Wu, Fengyi; Wu, Rong; Wang, Qian; Cao, Duojun.
Affiliation
  • Kong Y; Engineering Technology Center of Department of Education of Anhui Province, College of Chemistry and Materials Engineering, Chaohu University, Chaohu 238024, PR China.
  • Qin G; Engineering Technology Center of Department of Education of Anhui Province, College of Chemistry and Materials Engineering, Chaohu University, Chaohu 238024, PR China.
  • Liu Z; Engineering Technology Center of Department of Education of Anhui Province, College of Chemistry and Materials Engineering, Chaohu University, Chaohu 238024, PR China.
  • Cheng L; Engineering Technology Center of Department of Education of Anhui Province, College of Chemistry and Materials Engineering, Chaohu University, Chaohu 238024, PR China.
  • Wang C; School of Biological and Environmental Engineering, Chaohu University, Chaohu 238024, PR China.
  • Wu F; Engineering Technology Center of Department of Education of Anhui Province, College of Chemistry and Materials Engineering, Chaohu University, Chaohu 238024, PR China.
  • Wu R; Engineering Technology Center of Department of Education of Anhui Province, College of Chemistry and Materials Engineering, Chaohu University, Chaohu 238024, PR China. Electronic address: wurong@chu.edu.cn.
  • Wang Q; Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun 130000, PR China. Electronic address: wangqian1991@jlu.edu.cn.
  • Cao D; Engineering Technology Center of Department of Education of Anhui Province, College of Chemistry and Materials Engineering, Chaohu University, Chaohu 238024, PR China. Electronic address: 053076@chu.edu.cn.
Spectrochim Acta A Mol Biomol Spectrosc ; 323: 124922, 2024 Dec 15.
Article in En | MEDLINE | ID: mdl-39096671
ABSTRACT
It has been well established that Hydrogen sulfide (H2S) is involved in various pathophysiological processes. Therefore, accurate monitoring H2S levels in vitro or vivo is of great significance in biological systems. Herein, we firstly developed a thiomaleimide-based compound MAL-1 bearing aggregation-induced emission characteristic for selective response toward H2S due to its nucleophilicity. The proposed sensor presented prominent sensitivity and selectivity with low detection limit of 75 nM and pseudo-first-order reaction rate constant of 9.65 × 10-2 s-1, as well as low cytotoxicity which works well in recognizing H2S in real samples and visualizing H2S in living cells. Thus, it could be concluded that the novel thiomaleimide-based probe would be a promising tool for assessing intracellular H2S levels.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fluorescent Dyes / Hydrogen Sulfide Limits: Humans Language: En Journal: Spectrochim Acta A Mol Biomol Spectrosc Journal subject: BIOLOGIA MOLECULAR Year: 2024 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fluorescent Dyes / Hydrogen Sulfide Limits: Humans Language: En Journal: Spectrochim Acta A Mol Biomol Spectrosc Journal subject: BIOLOGIA MOLECULAR Year: 2024 Document type: Article