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The novel stimulators of feline ovarian granulosa cell functions: Monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1.
Sirotkin, Alexander V; Fabová, Zuzana; Loncová, Barbora; Harrath, Abdel Halim.
Affiliation
  • Sirotkin AV; Factulty of Natural Sciences and Informatics, Constantine the Philosopher University in Nitra, Nitra, Slovakia. Electronic address: asirotkin@ukf.sk.
  • Fabová Z; Factulty of Natural Sciences and Informatics, Constantine the Philosopher University in Nitra, Nitra, Slovakia.
  • Loncová B; Factulty of Natural Sciences and Informatics, Constantine the Philosopher University in Nitra, Nitra, Slovakia.
  • Harrath AH; Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Reprod Biol ; 24(3): 100926, 2024 Sep.
Article in En | MEDLINE | ID: mdl-39106594
ABSTRACT
The aim of the present study was to determine whether adipokines monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) can affect the functions of ovarian cells in cats. The addition of either MCP-1 or PAI-1 increased viability; promoted the accumulation of proliferation markers and progesterone and estradiol release; and decreased the accumulation of apoptosis markers in cultured feline granulosa cells. The present observations suggest that MCP-1 or PAI-1 can be physiological stimulators of ovarian granulosa cell functions.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasminogen Activator Inhibitor 1 / Chemokine CCL2 / Granulosa Cells Limits: Animals Language: En Journal: Reprod Biol Journal subject: MEDICINA REPRODUTIVA Year: 2024 Document type: Article Country of publication: Poland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasminogen Activator Inhibitor 1 / Chemokine CCL2 / Granulosa Cells Limits: Animals Language: En Journal: Reprod Biol Journal subject: MEDICINA REPRODUTIVA Year: 2024 Document type: Article Country of publication: Poland