Advances in the understanding of androgen receptor structure and function and in the development of next-generation AR-targeted therapeutics.
Steroids
; 210: 109486, 2024 Oct.
Article
in En
| MEDLINE
| ID: mdl-39111362
ABSTRACT
Androgen receptor (AR) and its ligand androgens are important for development and physiology of various tissues. AR and its ligands also play critical role in the development of various diseases, making it a valuable therapeutic target. AR ligands, both agonists and antagonists, are being widely used to treat pathological conditions, including prostate cancer and hypogonadism. Despite AR being studied widely over the last five decades, the last decade has seen striking advances in the knowledge on AR and discoveries that have the potential to translate to the clinic. This review provides an overview of the advances in AR biology, AR molecular mechanisms of action, and next generation molecules that are currently in development. Several of the areas described in the review are just unraveling and the next decade will bring more clarity on these developments that will put AR at the forefront of both basic biology and drug development.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Androgen
Limits:
Animals
/
Humans
Language:
En
Journal:
Steroids
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
United States