Advancements in the study of glucose metabolism in relation to tumor progression and treatment.
Prog Biophys Mol Biol
; 192: 11-18, 2024 Aug 05.
Article
in En
| MEDLINE
| ID: mdl-39111717
ABSTRACT
Sugar serves as the primary energy source for mammals, with glucose metabolism facilitating energy acquisition in human cells. The proper functioning of intracellular glucose metabolism is essential for the maintenance of orderly and healthy physiological activities. Tumor cells, characterized by uncontrolled growth, exhibit dysregulated proliferation and apoptosis processes, leading to abnormal alterations in glucose metabolism. Specifically, tumor cells exhibit a shift towards aerobic glycolysis, resulting in the production of lactic acid that can be utilized as a metabolic intermediate for sustained tumor cell growth. This article provides a comprehensive overview of the enzymes involved in glucose metabolism and the alterations in gene expression that occur during tumor progression. It also examines the current research on targeting abnormal glucose metabolism processes for tumor treatment and discusses potential future directions for utilizing glucose metabolism as a therapeutic target.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Prog Biophys Mol Biol
Year:
2024
Document type:
Article
Affiliation country:
China