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Alterations of the Fatty Acid Profile and the Expression of Genes Related to FA Metabolism in Cirrhotic Liver Tissue.
Hliwa, Aleksandra; Lange-Andrzejewska, Oliwia; Laski, Dariusz; Sledzinski, Maciej; Remiszewski, Piotr; Drobinska, Anna; Mika, Adriana; Sledzinski, Tomasz.
Affiliation
  • Hliwa A; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland.
  • Lange-Andrzejewska O; Department of Environmental Analytics, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
  • Laski D; Department of General, Endocrine and Transplant Surgery, Faculty of Medicine, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdansk, Poland.
  • Sledzinski M; Department of General, Endocrine and Transplant Surgery, Faculty of Medicine, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdansk, Poland.
  • Remiszewski P; Department of General, Endocrine and Transplant Surgery, Faculty of Medicine, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdansk, Poland.
  • Drobinska A; Department of Paediatrics, Nephrology and Hypertension, Faculty of Medicine, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdansk, Poland.
  • Mika A; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland.
  • Sledzinski T; Department of Environmental Analytics, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
Int J Mol Sci ; 25(15)2024 Jul 25.
Article in En | MEDLINE | ID: mdl-39125684
ABSTRACT
In addition to direct damage to hepatocytes, long-term ethanol consumption leads to lipid accumulation and hepatic steatosis, as well as to the dysregulation of lipid metabolism. The final step in various liver diseases is cirrhosis. The aim of this study was to compare the FA (fatty acids) profile and expression levels of genes involved in lipid metabolism in cirrhotic liver tissue and normal liver tissue. Exploring the changes in the FA profile and expression of genes related to fatty acid metabolism in cirrhotic liver tissue reveals a molecular landscape that goes beyond the surface of traditional liver function assessments. Understanding the shifts in gene expression and fatty acid composition in liver tissue opens avenues for interventions that may aid in the treatment of cirrhosis in the future.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lipid Metabolism / Fatty Acids / Liver / Liver Cirrhosis Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Int J Mol Sci Year: 2024 Document type: Article Affiliation country: Poland Country of publication: Switzerland
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lipid Metabolism / Fatty Acids / Liver / Liver Cirrhosis Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Int J Mol Sci Year: 2024 Document type: Article Affiliation country: Poland Country of publication: Switzerland