Sequential Nucleophilic Aromatic Substitution Reactions of Activated Halogens.
Int J Mol Sci
; 25(15)2024 Jul 26.
Article
in En
| MEDLINE
| ID: mdl-39125731
ABSTRACT
Building blocks have been identified that can be functionalised by sequential nucleophilic aromatic substitution. Some examples are reported that involve the formation of cyclic benzodioxin and phenoxathiine derivatives from 4,5-difluoro-1,2-dinitrobenzene, racemic quinoxaline thioethers, and sulfones from 2,3-dichloroquinoxaline and (2-aminophenylethane)-2,5-dithiophenyl-4-nitrobenzene from 1-(2-aminophenylethane)-2-fluoro-4,5-dinitrobenzene. Four X-ray single-crystal structure determinations are reported, two of which show short intermolecular N-O
N "π hole" contacts.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Halogens
Language:
En
Journal:
Int J Mol Sci
Year:
2024
Document type:
Article
Affiliation country:
United kingdom
Country of publication:
Switzerland