Avian and Human Influenza A Virus Receptors in Bovine Mammary Gland.

Kristensen, Charlotte; Jensen, Henrik E; Trebbien, Ramona; Webby, Richard J; Larsen, Lars E

Kristensen, Charlotte; Jensen, Henrik E; Trebbien, Ramona; Webby, Richard J; Larsen, Lars E.

Emerg Infect Dis ; 30(9): 1907-1911, 2024 Sep.

Article in En | MEDLINE | ID: mdl-39127127

ABSTRACT

ABSTRACT

An outbreak of influenza A (H5N1) virus was detected in dairy cows in the United States. We detected influenza A virus sialic acid -α2,3/α2,6-galactose host receptors in bovine mammary glands by lectin histochemistry. Our results provide a rationale for the high levels of H5N1 virus in milk from infected cows.

Subject(s)

Mammary Glands, Animal; Orthomyxoviridae Infections; Receptors, Virus; Animals; Cattle; Mammary Glands, Animal/virology; Female; Receptors, Virus/metabolism; Humans; Orthomyxoviridae Infections/virology; Orthomyxoviridae Infections/veterinary; Influenza A Virus, H5N1 Subtype; Cattle Diseases/virology; Influenza, Human/virology; Milk/virology; Receptors, Cell Surface/metabolism; Influenza in Birds/virology; Influenza in Birds/epidemiology; Birds/virology

Key words

United States; cattle; host tropism; influenza; influenza A virus; receptor; sialic acid; viruses

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Virus / Orthomyxoviridae Infections / Mammary Glands, Animal Limits: Animals / Female / Humans Language: En Journal: Emerg Infect Dis Journal subject: DOENCAS TRANSMISSIVEIS Year: 2024 Document type: Article Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA

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