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Changes in glomerular filtration rate in patients with body mass index ≥35 kg/m2 treated with metabolic and bariatric surgery versus GLP-1 agonist at 1-year follow-up.
Henao-Carrillo, Diana Cristina; Jurado-Florez, Mayra Alejandra; Muñoz, Óscar Mauricio.
Affiliation
  • Henao-Carrillo DC; Pontificia Universidad Javeriana Bogotá Colombia.
  • Jurado-Florez MA; Endocrinology Unit Hospital Universitario San Ignacio Bogotá Colombia.
  • Muñoz ÓM; Pontificia Universidad Javeriana Bogotá Colombia.
Obes Sci Pract ; 10(4): e782, 2024 Aug.
Article in En | MEDLINE | ID: mdl-39130193
ABSTRACT

Background:

Metabolic and bariatric surgery (MBS) reduces glomerular hyperfiltration. The renoprotective effects of GLP-1 analogs were derived from clinical studies in type 2 diabetes (T2D). The objective of this study was to evaluate the changes in glomerular filtration rate (GFR) over time associated with weight loss in patients with a BMI ≥ 35 kg/m2 treated with liraglutide compared with patients treated with MBS.

Methods:

A longitudinal study derived from a retrospective cohort of patients with BMI ≥ 35 kg/m2 treated with either MBS or liraglutide 3 mg/day, with follow-up ≥1 year. Clinical variables, baseline GFR, and 1-year GFR were analyzed. A generalized estimating equation (GEE) model was used to compare changes in GFR between both groups while controlling for confounding variables.

Results:

A total of 159 patients were included in the analysis. Of these, 129 patients underwent MBS (median age 60.5 years [IQR 51.8-66.6], body mass index (BMI) 40.9 kg/m2 [IQR 0.68-0.89]), and 30 patients were treated with liraglutide (median age 56 years [IQR 46-62], BMI 37.4 kg/m2 [IQR 0.69-0.93]). No difference in baseline GFR or at 12 months of follow-up was found between the two interventions. GEE analysis revealed an increase of 0.32 mL/min/1.73 m2 per month of follow-up. Factors associated with a greater increase in GFR were the percentage total weight loss (%TWL) (0.12 mL/min/1.73 m2, p = 0.023) and baseline GFR (0.69 mL/min/1.73 m2, p > 0.001) for both interventions, independent of a history of T2D.

Conclusion:

In patients with BMI ≥ 35 kg/m2, changes in GFR are related to %TWL and baseline GFR, regardless of the presence of diabetes or the type of intervention used.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Obes Sci Pract Year: 2024 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Obes Sci Pract Year: 2024 Document type: Article Country of publication: United States