Kopsileuconines A-D: Bisindole alkaloids with cytotoxic activity from Kopsia hainanensis.
Phytochemistry
; 228: 114245, 2024 Dec.
Article
in En
| MEDLINE
| ID: mdl-39134110
ABSTRACT
Kopsileuconines A-D (1-4), four monoterpenoid bisindole alkaloids with unprecedented skeletons, along with their biosynthetically related precursors (5-8) were isolated from the roots of Kopsia hainanensis. Compound 1 possessed an undescribed C-6-C-5' dimerization pattern of aspidofractinine-type alkaloids. Compounds 2-4 were rhazinilam-kopsine (2) and rhazinilam-aspidofractinine type (3 and 4) bisindole alkaloids with undescribed skeletons, respectively. Their structures with absolute configurations were fully accomplished by extensive spectroscopic analysis, quantum-chemical calculations, and X-ray crystallography. A plausible biosynthetic pathway for 1-4 was proposed. Compound 2 exhibited a significant inhibitory effect against human lung cancer cell lines PC9 (EGFR mutant), with an IC50 value of 15.07 ± 1.19 µM.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Screening Assays, Antitumor
/
Apocynaceae
/
Indole Alkaloids
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Language:
En
Journal:
Phytochemistry
Year:
2024
Document type:
Article
Country of publication:
United kingdom