Palladium-catalyzed syn-alkynylarylation of internal alkynes: rapid access to all-carbon tetrasubstituted alkenes.
Chem Commun (Camb)
; 60(71): 9578-9581, 2024 Aug 29.
Article
in En
| MEDLINE
| ID: mdl-39140162
ABSTRACT
Herein, a straightforward method for rapid access to all-carbon tertrasubstituted alkenes bearing alkyl, aryl and alkynyl groups is established via palladium-catalyzed three-component cross-coupling reaction of internal alkynes, haloalkynes and arylboronic acids. This protocol is characterized by a broad substrate scope and excellent chemo- and regioselectivities. The dual beneficial roles of silver salts in activating haloalkynes and inhibiting bromoalkynylation have been demonstrated by serving as both the Lewis acid and halide scavenger.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United kingdom