Your browser doesn't support javascript.
loading
Exosome prospects in the diagnosis and treatment of non-alcoholic fatty liver disease.
Tamimi, Amirhossein; Javid, Mona; Sedighi-Pirsaraei, Nasrin; Mirdamadi, Arian.
Affiliation
  • Tamimi A; School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
  • Javid M; School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
  • Sedighi-Pirsaraei N; School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
  • Mirdamadi A; School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Front Med (Lausanne) ; 11: 1420281, 2024.
Article in En | MEDLINE | ID: mdl-39144666
ABSTRACT
The growing prevalence of NAFLD and its global health burden have provoked considerable research on possible diagnostic and therapeutic options for NAFLD. Although various pathophysiological mechanisms and genetic factors have been identified to be associated with NAFLD, its treatment remains challenging. In recent years, exosomes have attracted widespread attention for their role in metabolic dysfunctions and their efficacy as pathological biomarkers. Exosomes have also shown tremendous potential in treating a variety of disorders. With increasing evidence supporting the significant role of exosomes in NAFLD pathogenesis, their theragnostic potential has become a point of interest in NAFLD. Expectedly, exosome-based treatment strategies have shown promise in the prevention and amelioration of NAFLD in preclinical studies. However, there are still serious challenges in preparing, standardizing, and applying exosome-based therapies as a routine clinical option that should be overcome. Due to the great potential of this novel theragnostic agent in NAFLD, further investigations on their safety, clinical efficacy, and application standardization are highly recommended.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Med (Lausanne) Year: 2024 Document type: Article Affiliation country: Iran Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Med (Lausanne) Year: 2024 Document type: Article Affiliation country: Iran Country of publication: Switzerland