Your browser doesn't support javascript.
loading
Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity.
Tian, Guilian; Bartas, Katrina; Hui, May; Chen, Lingxuan; Vasquez, Jose J; Azouz, Ghalia; Derdeyn, Pieter; Manville, Rían W; Ho, Erick L; Fang, Amanda S; Li, Yuan; Tyler, Isabella; Setola, Vincent; Aoto, Jason; Abbott, Geoffrey W; Beier, Kevin T.
Affiliation
  • Tian G; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Bartas K; Program in Mathematical, Computational, and Systems Biology, University of California, Irvine, Irvine, CA, USA.
  • Hui M; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Chen L; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Vasquez JJ; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Azouz G; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Derdeyn P; Program in Mathematical, Computational, and Systems Biology, University of California, Irvine, Irvine, CA, USA.
  • Manville RW; Bioelectricity Laboratory, Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Ho EL; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Fang AS; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Li Y; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Tyler I; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Setola V; Department of Neuroscience, West Virginia University, Morgantown, WV, USA; Department of Behavioral Medicine and Psychiatry, West Virginia University, Morgantown, WV, USA.
  • Aoto J; University of Colorado Anschutz School of Medicine, Department of Pharmacology, Aurora, CO, USA.
  • Abbott GW; Bioelectricity Laboratory, Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Beier KT; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA; Department of Neurobiology an
Neuron ; 112(20): 3470-3485.e12, 2024 Oct 23.
Article in En | MEDLINE | ID: mdl-39153478
ABSTRACT
The globus pallidus externus (GPe) is a central component of the basal ganglia circuit that acts as a gatekeeper of cocaine-induced behavioral plasticity. However, the molecular and circuit mechanisms underlying this function are unknown. Here, we show that GPe parvalbumin-positive (GPePV) cells mediate cocaine responses by selectively modulating ventral tegmental area dopamine (VTADA) cells projecting to the dorsomedial striatum (DMS). Interestingly, GPePV cell activity in cocaine-naive mice is correlated with behavioral responses following cocaine, effectively predicting cocaine sensitivity. Expression of the voltage-gated potassium channels KCNQ3 and KCNQ5 that control intrinsic cellular excitability following cocaine was downregulated, contributing to the elevation in GPePV cell excitability. Acutely activating channels containing KCNQ3 and/or KCNQ5 using the small molecule carnosic acid, a key psychoactive component of Salvia rosmarinus (rosemary) extract, reduced GPePV cell excitability and impaired cocaine reward, sensitization, and volitional cocaine intake, indicating its therapeutic potential to counteract psychostimulant use disorder.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cocaine / Ventral Tegmental Area / Globus Pallidus Limits: Animals Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2024 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cocaine / Ventral Tegmental Area / Globus Pallidus Limits: Animals Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2024 Document type: Article Affiliation country: United States Country of publication: United States